The A215 is an A road in south London, starting at Elephant and Castle and finishing around Shirley. It runs through the London Boroughs of Lambeth, Southwark and Croydon.

Beginning as Walworth Road, the A215 becomes Camberwell Road—much of which is a conservation area—after entering the former Metropolitan Borough of Camberwell. Crossing the A202, the A215 becomes Denmark Hill, originally known as Dulwich Hill, but renamed in 1683 to commemorate the marriage of Princess Anne (later Queen Anne) to Prince George of Denmark. After passing Herne Hill railway station the road becomes Norwood Road, Knights Hill, and then Beulah Hill at its crossroads with the A214. Beulah Hill was the site of the Croydon transmitting station, Britain's first independent television transmitter, built by the Independent Television Authority in 1955. Descending towards South Norwood the A215 becomes South Norwood Hill and then Portland Road, just after crossing the A213. A short section starting at the junction with Woodside Green is known as Spring Lane, leading to Shirley Road, the final section into Shirley, Croydon.

The A215 was Britain's most crash-prone A road between 1999 and 2010, having 2,836 crashes over its ten-mile length.